Key result
Head-up tilt induces syncope ~30 minutes earlier in elderly patients than healthy controls.
Why the study?
The mechanisms causing syncope in patients over the age of 60 with recurrent unexplained syncope were not well understood.
Population
10 patients over 60 with recurrent unexplained syncope and 5 controls
Comparison
Patients with recurrent syncope vs controls without syncope
Design
Case-control study with 60 minutes of 60 degree head-up tilt
Authors
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May inform diagnostic evaluation of unexplained syncope in elderly patients; leaves open prospective validation of clinical utility.
Case-Control (n=15)
Absolute Event Rate: 22% vs 52%
p-value: p=0.05
Hackel et al. (1991) conducted a case-control in Recurrent unexplained syncope (n=15). 60 degree head-up tilt vs. Controls with no history of syncope was evaluated on Time to syncope or pre-syncope (p=0.05). Head-up tilt induced syncope or pre-syncope significantly earlier in elderly patients with unexplained syncope compared to healthy controls (median time 22 vs 52 minutes, P=0.05).
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