Why the study?
Does recombinant human GH replacement therapy alter thyroid function in adult patients with severe GH deficiency?
Does recombinant human GH replacement therapy alter thyroid function in adult patients with severe GH deficiency?
Recombinant human GH replacement therapy in adults with severe GH deficiency can unmask or worsen central hypothyroidism, necessitating careful monitoring of thyroid function and potential initiation or adjustment of L-T4 therapy.
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Supports monitoring thyroid function during rhGH in GH-deficient adults; leaves open whether this alters long-term outcomes in trials.
Porretti et al. (2002) studied this question.
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