Why the study?
Due to its dual roles in tumor progression and immune regulation, FAT2 has emerged as a potential biomarker and therapeutic target in human diseases.
Design
Review
This review highlights the emerging role of the FAT2 gene in tumor progression, immune regulation, and neurological disorders, suggesting its potential as a therapeutic target.
Background: FAT2 is a member of the atypical cadherin family, characterized by a large extracellular structure and PDZ-binding domains, and is involved in cell adhesion, polarity maintenance, and migration. Recent studies have revealed that FAT2 plays a key role in the development of multiple diseases, particularly tumors and neurological disorders. In various cancers, FAT2 mutations or expression changes are linked to epithelial-mesenchymal transition, immune microenvironment remodeling, and therapeutic response. In the nervous system, FAT2 is essential for synaptic integrity and motor function, with mutations associated with cerebellar ataxia and neurodegeneration. Due to its dual roles in tumor progression and immune regulation, FAT2 has attracted growing interest as a potential biomarker and therapeutic target. This review summarizes the latest findings on the functional roles, regulatory pathways, and clinical significance of FAT2 in human diseases.
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Deng et al. (2025) studied this question.
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