Why the study?
What factors are associated with day-by-day variability in home blood pressure among patients treated with antihypertensive drugs?
What factors are associated with day-by-day variability in home blood pressure among patients treated with antihypertensive drugs?
Patient demographics, baseline hemodynamics, and specific antihypertensive drug classes (such as amlodipine vs ARBs) significantly influence day-by-day home blood pressure variability.
We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home heart rate, body mass index, and duration of antihypertensive treatment were negatively associated with home BP variability. Moreover, not being medicated with amlodipine and being medicated with angiotensin II receptor blockers were associated with increased home systolic BP variability only among patients who were treated for less than 12 months.
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Ishikura et al. (2012) studied this question.
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