What question did this study set out to answer?

To evaluate whether a personalized family-based lifestyle intervention improves low-density lipoprotein cholesterol (LDL-C) and other cardiovascular risk factors among relatives of hospitalized cardiovascular disease patients.

November 1, 2008Circulation Cardiovascular Quality and OutcomesOpen Access

A Novel Family-Based Intervention Trial to Improve Heart Health: FIT Heart

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Why the study?

Does a personalized lifestyle intervention reduce LDL-C in healthy adult family members of patients hospitalized with CVD?

Population

501 healthy adult family members of patients hospitalized with cardiovascular disease.

Comparison

Special intervention with personalized risk… vs Control intervention (CIN).

Design

RCT, randomized

Follow-up

1 year

Authors

LMLori MoscaGeneral Cardiology HMHeidi MochariNewYork–Presbyterian Hospital MLMing LiaoSouth China Agricultural University

Discussion

Member takes

Implication

Does not support LDL-C reduction via personalized lifestyle intervention in this population; challenges assumptions about family-based behavioral strategies for primary prevention.

Key Points

To evaluate whether a personalized family-based lifestyle intervention improves low-density lipoprotein cholesterol (LDL-C) and other cardiovascular risk factors among relatives of hospitalized cardiovascular disease patients.
Randomized controlled clinical trial enrolling 501 healthy adult family members of hospitalized CVD patients (66% female; 36% nonwhite; mean age, 48 years) with 1-year follow-up (94% retention).
Compared a special intervention consisting of personalized screening, therapeutic lifestyle-change counseling, and physician progress reports against a standard control intervention.
Mean percent change in LDL-C did not differ significantly between the special intervention and control groups (-1% vs -2%, respectively; P=0.64; absolute change: -4.4 mg/dL vs -4.5 mg/dL).
HDL-C declined significantly in the control group (-3.2%; 95% CI, -5.1 to -1.3) but not in the special intervention group (+0.3%; 95% CI, -1.7 to +2.4; P=0.01).
Participants in the special intervention group achieved significantly greater improvements in diet score (P=0.04) and were more likely to exercise more than 3 days per week at 1 year (P=0.04).

Structured PICO

Does a personalized lifestyle intervention reduce LDL-C in healthy adult family members of patients hospitalized with CVD?

Population

501 healthy adult family members (mean age 48 years, 66% female, 36% nonwhite) of patients hospitalized with cardiovascular disease.

Intervention

Special intervention (SI) with personalized risk factor screening, therapeutic lifestyle-change counseling, and progress reports to physicians over 1 year.

Comparator

Control intervention (CIN).

Outcome

Mean percent change in low-density lipoprotein cholesterol (LDL-C) at 1 year.surrogate

A personalized lifestyle intervention for family members of hospitalized CVD patients did not significantly reduce LDL-C compared to a control intervention, though it improved diet and exercise habits.

Cite This Study

Mosca et al. (2008) studied this question.

synapsesocial.com/papers/6a880a46010a27dee476f199 https://doi.org/10.1161/circoutcomes.108.825786

Topics

Women and heart disease Cardiovascular prevention

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Implication

Does not support LDL-C reduction via personalized lifestyle intervention in this population; challenges assumptions about family-based behavioral strategies for primary prevention.

A Novel Family-Based Intervention Trial to Improve Heart Health: FIT Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A Novel Family-Based Intervention Trial to Improve Heart Health: FIT Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider