Measles virus macromolecular synthesis is similar in human T cells and monocytes, but infectious virus assembly or release is significantly reduced in monocytes.
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Indicates monocyte-specific restrictions on measles virus maturation; leaves open their role in pathogenesis and transmission.
Replication of measles virus (MV) in populations of peripheral blood mononuclear cells enriched for T cells and monocytes was studied using a temperature-sensitive mutant, MV ts38, and the parent counterpart, MV Lec. Stimulation of the cells was required for a full cycle of virus replication in both cell types. More infectious virus was released after stimulation from MV-infected populations enriched for T cells, T cell-enriched than from monocyte-enriched populations. However, similar amounts of viral mRNA, genomic RNA, and viral proteins of the expected size were found in both cell populations. The results indicate that MV-specific macromolecular synthesis is similar in both T cells and monocytes, but the assembly and (or) release of infectious virus is greatly reduced in monocytes as compared with T cells.
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Vydelingum et al. (1995) studied this question.
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