April 1, 2014Pharmacogenomics

Pharmacogenetic Landscape of Clopidogrel in North Indians Suggest Distinct Interpopulation Differences in Allele Frequencies

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Population

2128 Indo-Europeans residing in north India from a cross-sectional population-scale genome-wide dataset

Design

Cross-sectional

Authors

AGAnil K. GiriSungkyunkwan University NKNazir M. KhanEmory Healthcare ABAnalabha BasuNational Institute of Biomedical Genomics

Discussion

Member takes

Implication

May warrant ethnicity-specific clopidogrel considerations in Indians; leaves open prospective outcome trials before practice change.

Structured PICO

Population

2128 Indo-Europeans residing in north India from a cross-sectional population-scale genome-wide dataset

Comparator

Global population

Outcome

Population-scale allele frequencies of variants associated with clopidogrel pharmacogeneticssurrogate

North Indians exhibit distinct allele frequencies for clopidogrel pharmacogenetic variants compared to the global population, suggesting a higher prevalence of clopidogrel metabolizers.

Cite This Study

Giri et al. (2014) studied this question.

synapsesocial.com/papers/6a880c9cafcf99b77fbbf566 https://doi.org/10.2217/pgs.13.241

Topics

Dual antiplatelet therapy

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Pharmacogenetic Landscape of Clopidogrel in North Indians Suggest Distinct Interpopulation Differences in Allele Frequencies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Pharmacogenetic Landscape of Clopidogrel in North Indians Suggest Distinct Interpopulation Differences in Allele Frequencies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider