January 8, 1971Science
Chemically Induced Porphyria: Increased Microsomal Heme Turnover after Treatment with Allylisopropylacetamide
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Discussion
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Implication
Experimental study demonstrates accelerated microsomal heme breakdown in rats following allylisopropylacetamide exposure, suggesting a link between rapid turnover and enzyme induction.
Key Points
- Determine the impact of allylisopropylacetamide on hepatic microsomal heme degradation, cytochrome P450 levels, and delta-aminolevulinic acid synthetase induction.
- Treated rats with allylisopropylacetamide and assessed changes in microsomal heme and cytochrome P450 concentrations alongside delta-aminolevulinic acid synthetase induction.
- Tracked radioactive decay following isotopic labeling of the heme moiety in submicrosomal fractions to evaluate heme degradation rates.
- Allylisopropylacetamide administration triggered excessive induction of delta-aminolevulinic acid synthetase accompanied by a marked decline in microsomal heme and cytochrome P450 levels.
- Radioactive decay measurements revealed an increased rate of heme breakdown in submicrosomal particles of treated animals compared to controls.
Cite This Study
Meyer et al. (1971) studied this question.