Population
Mice and in vitro models (Cx30.2(+) cells of the atrioventricular node)
Comparison
Genetic deletion of MyoR vs Wild-type/control (implied)
Design
Preclinical
Authors
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MyoR emerges as a transcriptional regulator of AV delay in mice; leaves open its relevance to human conduction or nodal disease.
MyoR is a novel transcription factor that modulates cardiac conduction and AV delay by repressing Gata4-dependent Cx30.2 expression.
Harris et al. (2014) studied this question.
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