Why the study?
Does rectal premedication with diazepam, morphine, and hyoscine provide satisfactory sedation and adequate plasma levels in healthy children undergoing minor surgery?
Does rectal premedication with diazepam, morphine, and hyoscine provide satisfactory sedation and adequate plasma levels in healthy children undergoing minor surgery?
Rectal premedication with diazepam, morphine, and hyoscine provides satisfactory sedation and rapid peak plasma levels in children undergoing minor surgery without adverse ventilatory effects.
May support rectal premedication feasibility in children; hypothesis-generating and requires randomized confirmation before practice change.
Rectal premedication with diazepam, morphine and hyoscine has been used in 20 healthy children undergoing minor surgery. Satisfactory sedation was achieved in the majority of children and the anticholinergic effects were also adequate. Peak plasma levels of diazepam and morphine were reached within 30 minutes, and the plasma levels decreased after 2 hours. No adverse effects on ventilation were seen during anaesthesia.
No takes yet. Share an insight, caveat, or question.
Lindahl et al. (1981) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: