Why the study?
Does a mixture of diazepam, morphine, and hyoscine compared to diazepam alone improve sedative and anticholinergic effects in healthy children undergoing minor elective surgery?
Does a mixture of diazepam, morphine, and hyoscine compared to diazepam alone improve sedative and anticholinergic effects in healthy children undergoing minor elective surgery?
A rectal premedication mixture of diazepam, morphine, and hyoscine offers no significant advantage over diazepam alone for sedation and anticholinergic effects in children undergoing minor surgery.
Answers are grounded in this paper and cite their sources.
Offers no advantage over diazepam alone for pediatric premedication; confirms monotherapy suffices in minor surgery.
Two hundred and eight healthy children who were to undergo minor elective surgery during halothane, nitrous oxide, oxygen anaesthesia were studied in a double blind investigation to evaluate the sedative and anticholinergic effects of two rectal premedications. Group I received diazepam 0.75 mg/kg rectally; Group II received a mixture of diazepam 0.5 mg/kg, morphine 0.15 mg/kg and hyoscine 0.01 mg/kg rectally. No significant difference was found between the two groups in sedative or anticholinergic effects during induction of anaesthesia or in the postoperative period. No adverse effects were seen.
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Rolf Haagensen (1985) studied this question.
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