The in vitro fluoride acquired by human enamel after application of APF, Duraphat (a resin varnish) and Fluor Protector (a polyurethane varnish), respectively, and subjected to various procedures was determined. Fluoride acquisition was the greatest in teeth treated with Duraphat and Fluor Protector and the least in APF-treated teeth. Fluoride uptake and distribution were not increased by extending the contact time between the topical fluoride agents and enamel from 4 to 24 h. Reapplication of the topical fluoride agents did not increase fluoride acquisition. Fluorapatite was the predominant reaction product with Duraphat and Fluor Protector and alkali-soluble fluorides with APF application.
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Retief et al. (2009) studied this question.