Flavonoids inhibit the platelet TxA2signalling pathway and antagonize TxA2receptors (TP) in platelets and smooth muscle cells

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Population

Platelets, human myometrium, and TPα- and TPβ-transfected HEK 293T cells

Design

Preclinical

Authors

Discussion

Hypothesis-generating for TxA2 antagonism by flavonoids; prospective human studies needed before any clinical consideration.

Population

Platelets, human myometrium, and TPα- and TPβ-transfected HEK 293T cells

Intervention

Flavonoids (apigenin, genistein, luteolin, and quercetin)

Outcome

Effect on U46619-induced calcium mobilization, tyrosine phosphorylation, ERK 1/2 activation, and binding to TxA2 receptors (TP)surrogate

Flavonoids inhibit platelet function by antagonizing TxA2 receptors and abrogating downstream signalling across multiple cell types.

Guerrero et al. (2007) studied this question.

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