Secondary Signalling Mechanisms in Angiotensin Ii‐stimulated Vascular Smooth Muscle Cells
Population
Vascular smooth muscle cells
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Should not alter clinical hypertension management; leaves open translation of IP3-DG crosstalk to human vascular disease.
Structured PICO
P
Population
Vascular smooth muscle cells
I
Intervention
Angiotensin II stimulation
O
Outcome
Secondary signalling mechanisms (generation of IP3 and DG, calcium mobilization, protein kinase C activation)surrogate
Angiotensin II stimulation in vascular smooth muscle cells triggers a complex interaction between IP3 and DG second messenger systems to mediate cellular responses.
Cite This Study
Griendling et al. (1988) studied this question.