Angiotensin II stimulates PLC activity via tyrosine phosphorylation of the gamma1 isoenzyme in VSMC and mesangial cells, mediating contractile and growth-stimulating effects.
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Hypothesis-generating in animal VSMCs; leaves open whether tyrosine kinase inhibition modifies AngII effects in human hypertension or CKD.
Marrero et al. (1996) studied this question.
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