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September 15, 1994Biochemical JournalOpen Access

Shear-stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s)

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Population

Washed platelets

Comparison

Fluid shear stress in a cone-plate viscometer… vs Baseline or different shear stress conditions…

Design

Preclinical

Authors

KRKuldeep RazdanUnited States Department of Veterans AffairsJHJ. D. HellumsRice UniversityMKMichael H. KrollThe University of Texas MD Anderson Cancer Center

Discussion

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Overview

May inform shear-stress platelet signaling targets; leaves open relevance to human thrombosis.

Structured PICO

P
Population
Washed platelets
I
Intervention
Fluid shear stress (0.3 to 0.9 mN/cm2) in a cone-plate viscometer, with or without exogenous purified human vWF, vWF binding inhibitors, EGTA, or cytochalasin D
C
Comparator
Baseline or different shear stress conditions without vWF or inhibitors
O
Outcome
Protein tyrosine phosphorylation (PTP) of substratessurrogate

Tyrosine phosphorylation is involved in transmembrane signaling that mediates platelet adhesion and aggregation in response to pathological shear stresses.

Cite This Study

Razdan et al. (1994) studied this question.

synapsesocial.com/papers/6a8812e0afcf99b77fbbf762https://doi.org/10.1042/bj3020681
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies with a murine monoclonal antibody that abolishes ristocetin- induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor1983 · 462 citations
  2. 2Biochemical mechanisms of platelet activation1989 · 368 citations
  3. 3Vanadate activates platelets by enhancing arachidonic acid release1993 · 31 citations
  4. 4Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton1988 · 2,130 citations
  5. 5Substrate affinity of the protein tyrosine kinase pp60c-src is increased on thrombin stimulation of human platelets1993 · 30 citations