Key result
Metal implants such as silver clips or 125I seeds did not cause a significant thermal effect on radiofrequency ablation in in-vitro porcine livers, with no significant difference in temperatures compared to control tissue.
Why the study?
Does the presence of metal implants (silver clips or 125I seeds) affect the thermal field and ablation scope during radiofrequency ablation in an in-vitro porcine liver model?
Does the presence of metal implants (silver clips or 125I seeds) affect the thermal field and ablation scope during radiofrequency ablation in an in-vitro porcine liver model?
Metal implants located 1 cm away from the RF electrode do not significantly alter the thermal field or ablation scope during radiofrequency ablation in an in-vitro porcine liver model.
Answers are grounded in this paper and cite their sources.
No thermal interference from implants in this model; leaves open clinical safety and human validation.
BACKGROUND: To explore metal implants' thermal effect on radiofrequency ablation (RFA) and ascertain distance-thermal relationship between the metal implants and radiofrequency (RF) electrode. METHODS: Metal implants models were established in seven in-vitro porcine livers using silver clips or 125I seeds. RFA were conducted centering the RF electrode axis1 cm away from them, with one side containing a metal implants model the test group and the other side the control group. The thermometric needles were used to measure multi-point temperatures in order to compare the time-distance-temperature difference between the two groups. The gross scopes of the ablation of the two groups were measured and the tissues were analyzed for microscopic histology. RESULTS: At the ablation times of 8, 12, and 15 min, the average multi-point temperatures of the test group and the control group were 48.2±18.07°C, 51.5±19.57°C, 54.6±19.75°C, and 48.6±17.69°C, 52.2±19.73°C, 54.9±19.24°C, respectively, and the differences were not statistically significant (n=126, P>0.05). At the ablation times of 12 and 15 min, the ablation scopes of the test group and the control group were (horizontal/longitudinal diameter) 1.55/3.48 cm, 1.89/3.72 cm, and 1.56/3.48 cm, 1.89/3.72 cm, respectively, and the differences were not statistically significant (n=14, P>0.05). The two groups had the same manifestations in microscopy. CONCLUSIONS: Metal implants do not cause significant thermal effect on RFA.
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Lin et al. (2013) studied In-vitro porcine liver models simulating metal implants (n=7). Metal implants (silver clips or 125I seeds) vs. Normal liver tissue (control group) was evaluated on Average multi-point temperature at 15 minutes of radiofrequency ablation (p=>0.05). Metal implants such as silver clips or 125I seeds did not cause a significant thermal effect on radiofrequency ablation in in-vitro porcine livers, with no significant difference in temperatures compared to control tissue.
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