Answers are grounded in this paper and cite their sources.
166 women received the oral contraceptive Anovlar (4 mg norethisterone acetate plus .05 mg ethinyl estradiol) on Cycle Days 5-24 for a total of 1023 cycles. A 100% efficiency rate was encountered. Side effects were few. Nausea occurred in 22% the first cycle and in only 7% by the seventh cycle. Dysmenorrhea improved or disappeared in 36% of the cases and got worse in none. The most frequent side effect was weight gain (more than 3 pounds in 45% of the cases). Breakthrough bleeding occurred in 5.1% spotting 9% and amenorrhea in 2.5% of all cycles. More than 60% reported a decrease in menstrual flow and premenstrual tension improved in 26% of the patients. No evidence of virilization was noted.
No takes yet. Share an insight, caveat, or question.
Mears et al. (1962) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: