Key result
A 50-80% basal rate reduction set 90 minutes pre-exercise reduced the incidence of hypoglycemia compared to pump suspension at exercise onset (5.9% vs 41.2%; P<0.05).
Why the study?
The timing and amount of basal rate reductions required to prevent exercise-associated hypoglycemia in individuals with type 1 diabetes on continuous subcutaneous insulin infusion remain unclear.
Does a 50-80% basal rate reduction 90 minutes pre-exercise reduce exercise-associated hypoglycemia compared to pump suspension at exercise onset in individuals with type 1 diabetes on continuous subcutaneous insulin infusion?
Population
17 individuals with type 1 diabetes on continuous subcutaneous insulin infusion
Comparison
80% BRR vs 50% BRR 90 min pre-exercise vs pump suspension at exercise onset
Design
Randomized crossover trial
Authors
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Reduces exercise hypoglycemia risk in T1D pump users; extends RCT evidence for preemptive basal adjustment over suspension.
RCT (n=17)
crossover
Does a 50-80% basal rate reduction 90 minutes pre-exercise reduce exercise-associated hypoglycemia compared to pump suspension at exercise onset in individuals with type 1 diabetes on continuous subcutaneous insulin infusion?
Absolute Event Rate: 5.9% vs 41.2%
p-value: p=<0.05
Setting a 50-80% basal rate reduction 90 minutes before aerobic exercise significantly reduces the risk of exercise-associated hypoglycemia compared to pump suspension at exercise onset in patients with type 1 diabetes.
Zaharieva et al. (2019) conducted an RCT in Type 1 diabetes on continuous subcutaneous insulin infusion (n=17). Basal rate reduction (BRR) vs. Pump suspension (PS) at exercise onset was evaluated on Development of hypoglycemia (p=<0.05). A 50-80% basal rate reduction set 90 minutes pre-exercise reduced the incidence of hypoglycemia compared to pump suspension at exercise onset (5.9% vs 41.2%; P<0.05).
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