Key result
Left ventricular reverse remodeling was independently associated with an 84% reduced risk of long-term cardiovascular death, heart transplantation, or heart failure hospitalization (HR 0.16).
Why the study?
What are the predictors of left ventricular reverse remodeling and its prognostic role in patients with nonischemic dilated cardiomyopathy?
Population
329 consecutive hospitalized patients with nonischemic dilated cardiomyopathy, of which 253 had clinical and…
Design
Cohort
Follow-up
Midterm follow-up at 16 ± 7 months, followed long-term…
Authors
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Supports midterm LV remodeling assessment for prognosis in nonischemic DCM; hypothesis-generating for intervention trials.
Cohort (n=329)
No
What are the predictors of left ventricular reverse remodeling and its prognostic role in patients with nonischemic dilated cardiomyopathy?
Hazard Ratio: 0.16 (95% CI 0.07–0.38)
p-value: p=<0.001
In patients with nonischemic dilated cardiomyopathy, monitoring left ventricular structure and NT-proBNP levels at midterm follow-up is clinically useful for predicting long-term prognosis.
Choi et al. (2012) conducted a cohort in Nonischemic dilated cardiomyopathy (n=329). Left ventricular reverse remodeling (LVRR) vs. Absence of LVRR was evaluated on Combined clinical events of cardiovascular death, heart transplantation, or hospitalization for heart failure (HR 0.16, 95% CI 0.07-0.38, p=<0.001). Left ventricular reverse remodeling was independently associated with an 84% reduced risk of long-term cardiovascular death, heart transplantation, or heart failure hospitalization (HR 0.16).
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