Recent Trends in Achievement Rates and Time Required for Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy

Figures

• 

  Figure 1.. Receiver operating characteristic (ROC) analysis for predicting LVRR. The area under the curve (AUC) and cutoff value of β-blocker dose (A) and level of BNP at discharge (B) were 0.78 and 15 mg/day of carvedilol (sensitivity, 0.78; specificity, 0.67), 0.74 and 119 pg/mL (sensitivity, 0.74; specificity, 0.77), respectively. BNP, B-type natriuretic peptide; LVRR, left ventricular reverse remodeling.

• 

  Figure 2.. (A) Proportion of LVRR by year of diagnosis. LVRR was observed in 31 of 64 patients (48%) in the first period (2007–2017), and significantly increased to 51 of 57 patients (89%) in the second period (2018–2022). (B) Change in LVEF at discharge and follow-up. The mean maximum LVEF at follow-up was 43.6% for the first period and 54.4% for the second period. (C) Comparison of ∆LVEF between the first and second time periods. ∆LVEF was significantly higher in the second period than in the first. LVEF, left ventricular ejection fraction; LVRR, left ventricular reverse remodeling.

• 

  Figure 3.. Histogram of the time to LVRR in 82 patients with LVRR. (A) The median time to LVRR was 208 days (interquartile range: 138–396 days). (B) Time to LVRR was significantly shorter in the second period than in the first, LVRR, left ventricular reverse remodeling.

• 

  Figure 4.. Kaplan-Meier analysis of LVRR achievement. In both the first and second time periods the rate of LVRR achievement reached a plateau in approximately 2 years, and LVRR was rarely observed thereafter. LVRR, left ventricular reverse remodeling.