Key result
Higher rGLPS is linked to ~88% greater odds of LV reverse remodelling in DCM.
Why the study?
Left ventricular reverse remodelling (LVRR) is an important therapeutic objective in DCM associated with favourable outcomes, but independent baseline CMR predictors of LVRR needed investigation.
Do baseline CMR parameters (LVRI and rGLPS) predict left ventricular reverse remodelling in patients with dilated cardiomyopathy?
Comparison
Patients achieving LVRR vs those who did not
Design
Cohort study
Follow-up
Median 9 [interquartile range, 7-12] months
Authors
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LVRI and rGLPS were associated with LVRR in DCM; hypothesis-generating for CMR-based stratification pending prospective validation.
Observational (n=98)
No
Do baseline CMR parameters (LVRI and rGLPS) predict left ventricular reverse remodelling in patients with dilated cardiomyopathy?
Odds Ratio: 1.88 (95% CI 1.18–3.01)
p-value: p=0.008
Baseline CMR parameters, specifically the left ventricular remodelling index and the ratio of global longitudinal peak strain, are independent predictors of left ventricular reverse remodelling in patients with dilated cardiomyopathy.
Kan et al. (2023) conducted an observational in Dilated cardiomyopathy (n=98). Baseline CMR parameters (LVRI and rGLPS) vs. Lower baseline values was evaluated on Left ventricular reverse remodelling (LVRR) (OR 1.88, 95% CI 1.18-3.01, p=0.008). Baseline ratio of global longitudinal peak strain (rGLPS) and left ventricular remodelling index (LVRI) independently predicted left ventricular reverse remodelling in dilated cardiomyopathy (OR 1.88 and 1.79 per SD, respectively).
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