Absolute LV contractile reserve measured by dobutamine stress CMR predicted change in LVEF at 12 months, with a 1% increase associated with a 0.4% increase in LVEF (P=0.02).
Why the study?
Better biomarkers are needed to predict left ventricular remodelling in patients with dilated cardiomyopathy.
Does CMR-derived LV contractile reserve predict change in LVEF over 12 months in patients with recent-onset dilated cardiomyopathy?
Population
56 participants including 34 recent-onset DCM patients and 22 controls
Design
Prospective study
Follow-up
12 months
Key result
Absolute LV contractile reserve measured by dobutamine stress CMR predicted change in LVEF at 12 months, with a 1% increase associated with a 0.4% increase in LVEF (P=0.02).
Authors
Discussion
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Member takes
Overview
May aid risk stratification for LVEF recovery in recent-onset DCM; leaves open whether contractile reserve should guide therapy or trials.
Study Design
Type
Cohort (n=56)
Structured PICO
Does CMR-derived LV contractile reserve predict change in LVEF over 12 months in patients with recent-onset dilated cardiomyopathy?
P
Population
56 participants, including 34 patients with recent-onset dilated cardiomyopathy and 22 controls, followed for 12 months to evaluate predictors of left ventricular remodeling.
E
Exposure
Cardiovascular magnetic resonance (CMR) assessment including dobutamine stress for contractile reserve, T1 mapping, myocardial strain, and late gadolinium enhancement
O
Outcome
Change in LV ejection fraction (LVEF) over 12 monthssurrogate
Main Result
Effect estimate: 0.4% increase in LVEF per 1% increase in contractile reserve
p-value: p=0.02
Low LV contractile reserve measured by dobutamine stress CMR identifies patients with recent-onset DCM whose LVEF is less likely to recover at 12 months.
Cite This Study
Tayal et al. (2020) conducted a cohort in Dilated cardiomyopathy (n=56). Absolute LV contractile reserve was evaluated on Change in LV ejection fraction (LVEF) over 12 months (0.4% increase in LVEF per 1% increase in contractile reserve, p=0.02). Absolute LV contractile reserve measured by dobutamine stress CMR predicted change in LVEF at 12 months, with a 1% increase associated with a 0.4% increase in LVEF (P=0.02).