Key result
Diabetic cardiomyopathy linked to a higher LV mass-to-volume ratio versus healthy controls.
Why the study?
Diabetic cardiomyopathy is accompanied by alterations in left ventricular structure and function, but detailed assessment of structural remodelling by cardiovascular magnetic resonance is needed.
Does cardiovascular magnetic resonance (CMR) identify structural remodelling differences in patients with diabetic cardiomyopathy compared to healthy controls?
Case-Control (n=56)
Does cardiovascular magnetic resonance (CMR) identify structural remodelling differences in patients with diabetic cardiomyopathy compared to healthy controls?
p-value: p=<0.05
CMR-derived mass-to-volume ratio (MVR) is significantly increased in diabetic cardiomyopathy and correlates with disease severity markers, suggesting its utility as an imaging biomarker for LV remodeling.
Background. Diabetic cardiomyopathy (DCM) is always accompanied with alteration of left ventricular structure and function. The aims of this study were to assess the structural remodelling in patients with DCM by cardiovascular magnetic resonance (CMR) and correlation of structural remodelling with severity of DCM. Methods. Twenty-five patients (53.8 ± 8.8 years, 52.0% males) with DCM and thirty-one normal healthy controls (51.9 ± 13.6 years, 45.2% males) were scanned by CMR cine to assess function and structure of left ventricular. Length of diabetic history and results of cardiac echocardiography (E', A', and E'/A') were also measured. Results. Compared with normal controls group, DCM group was associated with significantly increased ratio of left ventricular mass at end diastole to end-diastolic volume (MVR) (P < 0.05) and no significant difference was in mass at end diastole (P > 0.05). The ratio correlated with both length of diabetic history and echocardiographic Doppler tissue imaging E' (all P < 0.05). Conclusions. CMR can be a powerful technique to assess LV remodelling, and MVR may be considered as an imaging marker to evaluate the severity of LV remodelling in patients with DCM.
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Shang et al. (2016) conducted a case-control in Diabetic cardiomyopathy (n=56). Diabetic cardiomyopathy vs. Normal healthy controls was evaluated on Ratio of left ventricular mass at end diastole to end-diastolic volume (MVR) (p=<0.05). Diabetic cardiomyopathy was associated with a significantly increased ratio of left ventricular mass at end diastole to end-diastolic volume compared to healthy controls (P<0.05).
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