Key result
In asymptomatic diabetic patients, abnormal coronary flow velocity reserve (HR 12.918) and high total calcium score (HR 13.393) were independent predictors of major adverse cardiovascular events.
Why the study?
Does the joint assessment of coronary flow velocity reserve and calcium score predict major adverse cardiovascular and cerebrovascular events in asymptomatic diabetic patients?
Population
200 asymptomatic patients, mean age 57.7, 45.5% male. Includes 101 patients with diabetes mellitus on…
Design
Cohort
Follow-up
1 year
Authors
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Supports combined coronary flow velocity reserve and calcium scoring for risk stratification in asymptomatic diabetes; leaves open need for prospective outcome trials.
Cohort (n=200)
No
Does the joint assessment of coronary flow velocity reserve and calcium score predict major adverse cardiovascular and cerebrovascular events in asymptomatic diabetic patients?
Hazard Ratio: 12.918 (95% CI 3.865–43.177)
p-value: p=<0.001
Combined assessment of coronary flow velocity reserve and coronary artery calcium score provides independent and complementary prognostic information for predicting cardiovascular events in asymptomatic diabetic patients.
Dikic et al. (2015) conducted a cohort in Asymptomatic diabetes mellitus (n=200). Abnormal coronary flow velocity reserve (CFVR <2) vs. Normal coronary flow velocity reserve (CFVR ≥2) was evaluated on Major adverse cardiovascular and cerebrovascular events (MACCE) (HR 12.918, 95% CI 3.865-43.177, p=<0.001). In asymptomatic diabetic patients, abnormal coronary flow velocity reserve (HR 12.918) and high total calcium score (HR 13.393) were independent predictors of major adverse cardiovascular events.
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