Key result
Asymptomatic uncontrolled diabetes was associated with a significantly higher risk of significant coronary artery stenosis (OR 3.34) and subsequent cardiac events compared to normal individuals.
Why the study?
Data are limited regarding the impact of diabetes control on the risk of subclinical coronary atherosclerosis.
Does uncontrolled diabetes increase the risk of subclinical coronary atherosclerosis in asymptomatic patients?
Cohort (n=6,434)
No
Does uncontrolled diabetes increase the risk of subclinical coronary atherosclerosis in asymptomatic patients?
Odds Ratio: 3.34 (95% CI 2.52–4.43)
Absolute Event Rate: 22.6% vs 6.3%
p-value: p=<0.001
Uncontrolled diabetes in asymptomatic patients is associated with a higher burden of subclinical coronary atherosclerosis and subsequent cardiac events.
Uncontrolled diabetes may warrant closer atherosclerosis surveillance in asymptomatic patients; leaves open whether early intervention improves outcomes.
BACKGROUND: There are limited data on the impact of diabetes control on the risk of subclinical coronary atherosclerosis. METHODS: =368), respectively. RESULTS: =0.023). CONCLUSION: Asymptomatic uncontrolled diabetes was associated with significant subclinical coronary atherosclerosis with subsequent high risk for cardiac events.
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Park et al. (2019) conducted a cohort in Asymptomatic individuals without previous history of coronary artery disease (n=6,434). Uncontrolled diabetes (HbA1c ≥7%) vs. Normal individuals (no diabetes) was evaluated on Significant coronary artery stenosis (≥50% diameter stenosis) (OR 3.34, 95% CI 2.52-4.43, p=<0.001). Asymptomatic uncontrolled diabetes was associated with a significantly higher risk of significant coronary artery stenosis (OR 3.34) and subsequent cardiac events compared to normal individuals.
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