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Demonstrates that reserpine boosts tyrosine hydroxylase activity in rats entirely through protein accumulation, indicating regulation by increased enzyme synthesis rather than activation.
Chronic administration of reserpine to rats increases, in sympathetic ganglia and adrenal medulla, the activity of tyrosine hydroxylase (EC 1.14.3.x), the enzyme catalyzing the rate-limiting step in the biosynthesis of catecholamines. Immunochemical titration of the enzyme in both adrenal gland and innervated superior cervical ganglia demonstrates that enhanced enzyme activity is entirely attributable to accumulation of more specific enzyme protein and not activation of preexistent enzyme molecules.
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Joh et al. (1973) studied this question.
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