The time-related development of lymphocytotoxic antibodies in humans after skin homografting and/or intradermal leukocyte injection has been detailed. The antibodies were shown to reside chiefly in the γ2-globulin fraction of serum and to be individual-specific. They could be selectively adsorbed with positively-reacting cells. Various parameters of the cytotoxic test system were studied with emphasis on the nature of its “complement” requirement.
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Walford et al. (1965) studied this question.