Key result
Revascularization in high-risk NSTE-ACS was associated with reduced 6-month death, MI, or stroke in young (OR 0.69), elderly (OR 0.60), and very elderly (OR 0.72; 95% CI 0.54-0.95) patients.
Why the study?
Does revascularization reduce the risk of stroke, death, or myocardial infarction at 6 months in elderly and very elderly patients with high-risk NSTE-ACS?
Population
18,466 patients with high-risk non-ST-segment elevation acute coronary syndromes enrolled in the Global…
Comparison
Revascularization (early invasive strategy) vs Conservative management (no revascularization)
Design
Cohort
Follow-up
6 months
Authors
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May support revascularization in very elderly high-risk NSTE-ACS; extends observational data across ages but remains hypothesis-generating.
Cohort (n=18,466)
Yes
Does revascularization reduce the risk of stroke, death, or myocardial infarction at 6 months in elderly and very elderly patients with high-risk NSTE-ACS?
Odds Ratio: 0.72 (95% CI 0.54–0.95)
Revascularization for high-risk NSTE-ACS is associated with significant reductions in 6-month mortality and ischemic events across all age groups, including the very elderly, without increasing the risk of stroke.
Devlin et al. (2007) conducted a cohort in High-risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS) (n=18,466). Revascularization vs. No revascularization was evaluated on 6-month stroke, death, myocardial infarction (OR 0.72, 95% CI 0.54-0.95). Revascularization in high-risk NSTE-ACS was associated with reduced 6-month death, MI, or stroke in young (OR 0.69), elderly (OR 0.60), and very elderly (OR 0.72; 95% CI 0.54-0.95) patients.
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