Why the study?
Does age affect the hemodynamic responses to intravenous ephedrine in pediatric patients anesthetized with halothane and nitrous oxide?
Does age affect the hemodynamic responses to intravenous ephedrine in pediatric patients anesthetized with halothane and nitrous oxide?
In pediatric patients anesthetized with halothane and nitrous oxide, age correlates with the pressor but not the chronotropic effects of intravenous ephedrine.
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Age may influence ephedrine pressor response in halothane-anesthetized children; leaves open dosing implications and requires prospective validation.
The aim of this study was to evaluate the effect of age on the hemodynamic responses to intravenous (IV) ephedrine in pediatric patients anesthetized with halothane, nitrous oxide, and oxygen.One hundred ten pediatric patients, ranging in age from 0.1 to 15 yr, were assigned to receive 0.1 mg/kg (n = 55) or 0.2 mg/kg (n = 55) IV ephedrine. General anesthesia was maintained with 1.0 minimum alveolar anesthetic concentration (MAC) of halothane and 67% nitrous oxide in oxygen after tracheal intubation. Measurements of arterial blood pressure and heart rate were made at 1-min intervals for 10 min after ephedrine 0.1 or 0.2 mg/kg was injected IV as a bolus. Significant correlations were noted between age and changes in mean blood pressure (r = 0.37, P < 0.01 for the subjects receiving ephedrine 0.1 mg/kg; r = 0.63, P < 0.001 for the subjects receiving ephedrine 0.2 mg/kg), but not between age and changes in heart rate. The present results indicate that age correlates with the pressor but not the chronotropic effects of ephedrine in pediatric patients anesthetized with 1 MAC halothane and nitrous oxide. (Anesth Analg 1996;82:568-73)
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Taguchi et al. (1996) studied this question.
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