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The (pro)renin receptor is predominantly localized intracellularly, particularly in the endoplasmic reticulum, suggesting its primary role involves intracellular vesicle trafficking and V-ATPase function.
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Evidence suggests the (pro)renin receptor functions primarily as an intracellular protein involved in essential cellular processes like autophagy and V-ATPase regulation, challenging its traditional role solely as a cell surface receptor in the renin-angiotensin system.
Since its first report in 1996, the concept of the so-called (Pro)renin receptor ((P)RR/ATP6ap2) has dramactically evolved from a receptor mediating cellular effects of (pro)renin, to a protein with more basic and potentially essential intracellular functions. Among the arguments urging to reconsider the role of (P)RR was the observation that its localization appears mainly intracellular, although this does not preclude potential functions at the cell surface. However, despite about 10 years of research boosted by the generation of genetically modified animal models, the basic mechanisms of action of this protein at the cellular level remain elusive. This review aims at discussing the functions described for (P)RR in relation to its subcellular localization(s).
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Gabin Sihn (2012) reported a review. (Pro)renin receptor ((P)RR) was evaluated. The (pro)renin receptor is predominantly localized intracellularly, particularly in the endoplasmic reticulum, suggesting its primary role involves intracellular vesicle trafficking and V-ATPase function.
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