Population
Kidney tissue and collecting duct/distal tubule lineage Madin-Darby canine kidney cells
Design
Preclinical
Authors
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No immediate clinical implications for hypertension; hypothesis-generating for (P)RR function beyond RAS in distal nephron.
The (pro)renin receptor colocalizes with vacuolar H(+)-ATPase in the distal nephron, suggesting a primary function in H(+) transport rather than solely in renin-angiotensin system signaling.
Advani et al. (2009) studied this question.
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