Why the study?
Does exposure to norepinephrine or low temperature induce iNOS expression and nitric oxide production in rat brown adipocytes?
Population
Rat brown adipocytes differentiated in culture, and brown adipose tissue and brown adipocyte preparations…
Comparison
Exposure to norepinephrine, selective β1-, β2… vs Untreated cultures or room…
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open iNOS modulation of human brown adipose tissue function.
Does exposure to norepinephrine or low temperature induce iNOS expression and nitric oxide production in rat brown adipocytes?
Brown fat cells can express an inducible form of nitric oxide synthase dependent on sympathetic activity, which may modulate brown adipose tissue functions including microcirculation vasodilation.
Enzo Nisoli (1997) studied this question.
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