Key result
An increase in the ratio of high molecular weight adiponectin to total adiponectin was independently associated with a stable state of carotid intima media thickness in hemodialysis patients (OR 0.928, p=0.031).
Why the study?
Does the ratio of high molecular weight adiponectin to total adiponectin (HMWR) correlate with the progression of carotid intima-media thickness in hemodialysis patients?
Cohort (n=85)
No
Does the ratio of high molecular weight adiponectin to total adiponectin (HMWR) correlate with the progression of carotid intima-media thickness in hemodialysis patients?
An increase in the ratio of high molecular weight adiponectin to total adiponectin (HMWR) is associated with a stable state of carotid intima-media thickness in hemodialysis patients, suggesting a potential anti-atherogenic role.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for HMWR as a stability marker in hemodialysis; prospective trials needed before clinical adoption.
AIM: We investigated the parameters related to the progression of common carotid artery intima media thickness (IMT) in hemodialysis (HD) patients. METHODS: IMT was examined in 85 patients by ultrasonography at baseline and after 12 months. The difference in IMT between these two time points was calculated (DeltaIMT). We defined DeltaIMT< or =0.00 as 'progression', and DeltaIMT0.00 as 'stable'. Body fat distribution was calculated on computed tomography. Total adiponectin (T-Ad) and high molecular weight adiponectin (H-Ad) were measured by ELISA. RESULTS: There were no significant differences between the two groups in all profiles except for the ratio of H-Ad to T-Ad (HMWR) at baseline. In the 'progression' group, IMT increased from 1.56+/-0.89 to 1.77+/-0.94 mm (p<0.001) and visceral fat area (60.3+/-30.7 to 69.2+/-37.5, cm2; p<0.01) increased. In the 'stable' group, HMWR increased from 31.3+/-5.4 to 37.6+/-7.3% (p<0.001). Multiple logistic regression analysis selected DeltaHMWR (p=0.031, odds ratio=0.928) independently of IMT progression. The correlation coefficient was -0.254 (p=0.019) between DeltaIMT and DeltaHMWR. CONCLUSIONS: We found that an increase in HMWR was related to the stable state of IMT in HD patients.
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Tsushima et al. (2008) conducted a cohort in Atherosclerosis in hemodialysis patients (n=85). Change in ratio of high molecular weight adiponectin to total adiponectin (ΔHMWR) was evaluated on Progression of common carotid artery intima media thickness (ΔIMT > 0.00) (OR 0.928, p=0.031). An increase in the ratio of high molecular weight adiponectin to total adiponectin was independently associated with a stable state of carotid intima media thickness in hemodialysis patients (OR 0.928, p=0.031).
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