Penicillin and Sulfadiazine in the Treatment of Experimental Intraocular Infections With Staphylococcus Aureus and Clostridium Welchii

The study of the chemotherapy of intraocular infections of the anterior segment with Diplococcus pneumoniae¹was extended in these experiments to similar infections with Staphylococcus aureus, which stands second to D. pneumoniae in frequency as the cause of post-traumatic and postoperative purulent endophthalmitis, and Clostridium welchii was selected as a representative of the anaerobe group. The effect of the oral administration of sulfadiazine in combination with the topical use of its sodium salt was again compared with that of the local treatment with penicillin.² INFECTIONS WITH STAPHYLOCOCCUS AUREUS Preliminary Experiments. —Eight strains of Staph. aureus, obtained in cultures of material from human conjunctivas and corneas,³were tested in vitro for their sensitivity to penicillin. The determinations were made in accordance with the modified method of Fleming⁴except for the use of a 10⁻²dilution of the broth culture in place of a loopful of the