Distribution of Sulfanilamide and Its Derivatives Between Blood and Aqueous

There are abundant reports in the literature suggesting that sulfanilamide and its derivatives may revolutionize therapy in ophthalmology as they have in general medicine. It is the purpose of this study to investigate the diffusion of various sulfanilamide compounds into the eye, to evaluate the importance of paracentesis as a means of raising the level of the drug in the aqueous and to determine the correlation between data on animals and on human beings. In the treatment of intraocular infections it would seem important to know approximately the concentration of the chemotherapeutic agent that can be obtained in the aqueous. The studies reported here were carried out in the hope of amplifying this knowledge. Investigations have been made by Bellows and Chinn¹on the diffusion of sulfanilamide, sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) and sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) in the eye in dogs and by Meyer, Bloch and Chamberlain²on the diffusion of sulfapyridine