Jasplakinolide provides greater stabilization and rigidity to Ca-actin filaments compared to phalloidin.
These stabilization effects require cellular validation; leaves open whether jasplakinolide offers advantages in physiological or therapeutic contexts.
In this work the effect of phalloidin and jasplakinolide on the dynamic properties and thermal stability of actin filaments was studied. Temperature dependent fluorescence resonance energy transfer measurements showed that filaments of Ca-actin became more rigid in the presence of phalloidin or jasplakinolide. Differential scanning calorimetric data implied that the stiffer filaments also had greater thermal stability in the presence of phalloidin or jasplakinolide. The fluorescence and calorimetric measurements provided evidences that the extent of stabilization by jasplakinolide was greater than that by phalloidin.
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Visegrády et al. (2004) studied this question.
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