Key result
Jasplakinolide reduced the dynamics of actin and tropomyosin isoforms in cardiac mature myofibrils and premyofibrils, suggesting tropomyosin dynamics are related to actin exchange.
Why the study?
Does jasplakinolide alter the dynamics of actin and tropomyosin during myofibrillogenesis in cardiac and skeletal muscle cells?
Population
Cardiac and skeletal muscle cells (premyofibrils and mature myofibrils)
Comparison
Jasplakinolide vs Control muscle cells
Design
Preclinical
Authors
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Jasplakinolide stabilizes actin-tropomyosin dynamics in cardiac myofibrils; leaves open translation to human myofibrillogenesis or therapy.
Does jasplakinolide alter the dynamics of actin and tropomyosin during myofibrillogenesis in cardiac and skeletal muscle cells?
Jasplakinolide reduces actin and tropomyosin dynamics during myofibrillogenesis, suggesting that tropomyosin dynamics are related to actin exchange.
Wang et al. (2014) studied Cardiac and skeletal muscle myofibrillogenesis. Jasplakinolide vs. Control was evaluated on Dynamics of actin, tropomyosin, troponin, and Z-Band proteins. Jasplakinolide reduced the dynamics of actin and tropomyosin isoforms in cardiac mature myofibrils and premyofibrils, suggesting tropomyosin dynamics are related to actin exchange.
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