Why the study?
Does latrunculin B or jasplakinolide affect force fluctuation-induced relengthening in contracted canine tracheal smooth muscle?
Population
Canine tracheal smooth muscle (TSM) strips
Comparison
Latrunculin B or jasplakinolide, and their… vs Pretreatment values (baseline)
Design
Preclinical
Authors
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Actin filament length influences airway smooth muscle relengthening in canine models; hypothesis-generating for human asthma therapies and requires clinical translation.
Does latrunculin B or jasplakinolide affect force fluctuation-induced relengthening in contracted canine tracheal smooth muscle?
Actin filament length partially determines the relengthening of contracted airway smooth muscle, as demonstrated by the effects of actin-modulating agents latrunculin B and jasplakinolide.
Dowell et al. (2005) studied this question.
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