What question did this study set out to answer?

To determine whether cardiac sensory receptors elicit reflex relaxation of the stomach and to identify the specific nerve fibers and cardiac regions mediating this response.

February 1, 1972Acta Physiologica Scandinavica

Reflex Relaxation of the Stomach Elicited from Receptors Located in the Heart. An Analysis of the Receptors and Afferents Involved.

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Population

Cats anesthetized with chloralose

Design

Preclinical

Authors

HAHasse AbrahamssonDartmouth College PTPeter ThorénCross-Cutting Cardiology

Discussion

Member takes

Implication

No clinical translation yet; leaves open whether cardiac vagal afferents mediate human gastrocardiac reflexes.

Key Points

To determine whether cardiac sensory receptors elicit reflex relaxation of the stomach and to identify the specific nerve fibers and cardiac regions mediating this response.
Electrically stimulated the right cardiac nerve in chloralose-anesthetized cats while measuring afferent stimulation thresholds and conduction velocities.
Administered chemical stimulants (intrapericardial nicotine and intravenous veratrum alkaloids) and applied mechanical stimuli, including balloon occlusion of the aorta, pulmonary artery, and coronary artery.
Evaluated autonomic pathways using unilateral cervical vagal cooling or blockade and cervical vagal transection.
Electrical stimulation of unmyelinated vagal afferents in the cardiac nerve elicited immediate bradycardia, hypotension, and stomach relaxation, all of which were abolished by ipsilateral vagal blockade.
Mechanical stimulation of the left ventricle and coronary artery occlusion produced pronounced reflex gastric relaxation that was abolished by vagotomy, whereas pulmonary artery occlusion produced only minor gastric changes.
Intrapericardial nicotine and intravenous veratrum alkaloids replicated the gastric and circulatory reflexes, with veratrum-induced effects markedly reduced by intrapericardial local anesthesia.

Structured PICO

Population

Cats anesthetized with chloralose

Intervention

Electrical afferent stimulation of the right cardiac nerve, chemical stimulation (intrapericardial nicotine, intravenous veratrum alkaloids), or mechanical stimulation (occlusion of ascending aorta, mechanical stimulation of left ventricle, occlusion of coronary artery)

Outcome

Circulatory responses (hypotension, bradycardia) and gastric relaxationsurrogate

This preclinical study demonstrates that stimulation of unmyelinated vagal afferents from left ventricular receptors elicits a reflex relaxation of the stomach, potentially forming part of a vomiting pattern.

Cite This Study

Abrahamsson et al. (1972) studied this question.

synapsesocial.com/papers/6a882ab2c0c64b7dddeb3ec4 https://doi.org/10.1111/j.1748-1716.1972.tb05170.x

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