Key result
In healthy males, asymmetric dimethylarginine was significantly associated with the percentage increase in peak reactive hyperemia after exercise (β 165; 95% CI 34-296; p=0.02).
Why the study?
Is the difference in vasodilatory response before and after exercise related to endothelial and inflammatory biomarkers in healthy males?
Cross-Sectional (n=30)
Is the difference in vasodilatory response before and after exercise related to endothelial and inflammatory biomarkers in healthy males?
Effect estimate: β 165 (95% CI 34-296)
p-value: p=0.02
The difference in vasodilatory response before and after exercise correlates with endothelial and inflammatory biomarkers, suggesting its potential utility as a non-invasive marker of endothelial function.
ADMA association with post-exercise hyperemia is hypothesis-generating in healthy males; leaves open its value as non-invasive endothelial marker.
OBJECTIVES: Reduced arterial vasodilatatory capacity is a marker of coronary heart disease. The aim was to investigate if the difference between the vasodilatory response before and after exercise, as assessed by non-invasive methodology, is related to endothelial and inflammatory biomarkers. DESIGN: Post-ischemic hyperemia after 5 min of arterial occlusion was examined before and after a bicycle test with strain-gauge plethysmography (measuring peak reactive hyperemia in the forearm) and peripheral arterial tonometry (PAT hyperemia ratio: measuring pulse waves in the index finger relative to the contra-lateral index finger) in 30 healthy males. A low PAT hyperemia ratio or a low peak reactive hyperemia reflects endothelial dysfunction. Inflammatory and endothelial biomarkers were assessed. RESULTS: A low peak reactive hyperemia and a low PAT hyperemia ratio before the bicycle test was associated with a high percentage increase in peak reactive hyperemia after exercise (r = - 0.68, p < 0.001; r = - 0.35, p = 0.06, respectively). Asymmetric dimethylarginine and interleukin-10 were associated with the percentage increase in peak reactive hyperemia in multiple linear regression analyses (β: 165 (confidence interval [CI], 34-296), p = 0.02; β: 19 (CI, - 0.5-39), p = 0.06, respectively). CONCLUSIONS: The difference in the vasodilatory response before and after exercise, as assessed by non-invasive methodology, is related to endothelial and inflammatory biomarkers in healthy males.
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Wethal et al. (2015) conducted a cross-sectional in Healthy (n=30). Exercise (bicycle test) vs. Baseline (before exercise) was evaluated on Percentage increase in peak reactive hyperemia after exercise (β 165, 95% CI 34-296, p=0.02). In healthy males, asymmetric dimethylarginine was significantly associated with the percentage increase in peak reactive hyperemia after exercise (β 165; 95% CI 34-296; p=0.02).
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