Key result
Carotid angioplasty and stenting significantly improved cerebrovascular reactivity in patients with high-grade stenosis, increasing the ipsilateral breath holding index from 0.52 to 1.00 (p<0.001).
Why the study?
Carotid angioplasty and stenting is used for high-grade internal carotid artery stenosis, and cerebrovascular reactivity evaluated by breath holding index can assess post-procedure outcomes.
Does carotid angioplasty and stenting improve cerebrovascular reactivity in patients with symptomatic internal carotid artery high-grade stenosis?
Cross-Sectional (n=32)
Yes
Does carotid angioplasty and stenting improve cerebrovascular reactivity in patients with symptomatic internal carotid artery high-grade stenosis?
Absolute Event Rate: 1% vs 0.52%
p-value: p=< 0.001
Carotid angioplasty and stenting significantly improves cerebrovascular reactivity in patients with symptomatic high-grade internal carotid artery stenosis.
Supports improved reactivity after stenting; leaves open effects on clinical events in high-grade stenosis.
Internal carotid artery high-grade stenosis is a major cause of stroke. Carotid angioplasty and stenting (CAS) is a reasonable approach for treatment of certain patients. Cerebrovascular reactivity (CVR) evaluated through breath holding index test can assess the outcome following CAS. Evaluate changes in CVR before and after CAS. Thirty-two patients with 35 symptomatic internal carotid artery high-grade stenosis (> 70%) were enrolled by the mean of ultrasound screening. Breath holding index test was done using transcranial Doppler ultrasound before and after CAS. The study includes 32 patients (22 males and 10 females). The mean age was 61.91 ± 6.59 years. The main risk factor was hypertension (75.3%). All patients showed an increase in mean flow velocity and BHI following CAS ( P < 0.001) on both ipsilateral and contralateral side. Both groups (70–90% and > 90% stenosis) showed similar improvement of CVR. CAS improves CVR in all high grades of internal carotid artery stenosis.
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Hashem et al. (2019) conducted a cross-sectional in Symptomatic internal carotid artery high-grade stenosis (n=32). Carotid angioplasty and stenting (CAS) vs. Pre-CAS (baseline) was evaluated on Cerebrovascular reactivity evaluated by breath holding index (BHI) on the ipsilateral side (p=< 0.001). Carotid angioplasty and stenting significantly improved cerebrovascular reactivity in patients with high-grade stenosis, increasing the ipsilateral breath holding index from 0.52 to 1.00 (p<0.001).
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