Key result
In patients undergoing carotid artery stenting, the presence of calcified atherosclerotic plaques was a strong independent predictor of cerebrovascular insult at 12 months (OR 106.390).
Cross-Sectional (n=95)
No
Odds Ratio: 106.39 (95% CI 5.058–2237.887)
Absolute Event Rate: 66.7% vs 1.2%
p-value: p=0.003
In patients undergoing carotid artery stenting, advanced age and the presence of calcified plaques are strong independent predictors of post-procedural cerebrovascular insult.
Does not yet support routine plaque assessment before carotid stenting; leaves open its role in risk stratification pending prospective data.
Background: Carotid artery disease is a major cause of ischemic stroke, directly related to the severity of stenosis and presence of symptoms. Carotid artery stenting (CAS) is an endovascular, catheter-based procedure that unblocks stenoses of the carotid artery lumen to prevent a stroke. Objective: The aim of this study was to analyze outcomes in a series of patients with carotid atherosclerosis (CA) who underwent carotid angioplasty and stenting. Methods: This study was designed as a retrospective cross sectional study. The report includes 95 patients with carotid atherosclerosis who were treated with carotid angioplasty and stenting. The efficacy of the procedures was estimated by Doppler ultrasound of carotid arteries and by magnetic resonance imaging (MRI) 12 months after the procedure. Results: Observed complications after CAS included carotid artery restenosis in 8 (8,4% ) participants and CVI in 9 (9,5%) participants. We concluded that the appearance of CVI depends on the presence of distal protection devices (p =0.003). In contrast to CVI, restenosis of CA after angioplasty and stenting was not related to degree of CA stenosis (p = 0.600) nor to patient age (p = 0.264). Advanced age (p=0.024) and calcified atherosclerotic plaques (p=0.003) were independent predictors of CVI after the procedure. Conclusions: Carotid stenting can be considered the method of choice for the treatment of carotid disease.
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Marinković et al. (2011) conducted a cross-sectional in Carotid atherosclerosis (n=95). Calcified atherosclerotic plaques vs. Non-calcified plaques was evaluated on Cerebrovascular insult (CVI) after carotid artery stenting (OR 106.390, 95% CI 5.058-2237.887, p=0.003). In patients undergoing carotid artery stenting, the presence of calcified atherosclerotic plaques was a strong independent predictor of cerebrovascular insult at 12 months (OR 106.390).
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