Why the study?
Does candesartan reduce major cardiovascular events in elderly patients with mild hypertension?
Population
2,098 elderly patients with mild hypertension and preserved cognitive function who did not receive add-on…
Comparison
Candesartan 8-16 mg once daily for a mean… vs Placebo for a mean follow-up of 3.5 years.
Design
RCT, randomized, placebo-controlled
Follow-up
mean 3.7 years (candesartan) and 3.5 years (placebo)
Authors
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Supports candesartan in elderly mild hypertension; reinforces ARB recommendations for primary CV prevention.
Does candesartan reduce major cardiovascular events in elderly patients with mild hypertension?
Candesartan significantly reduces major cardiovascular events and mortality in elderly patients with mild hypertension, supporting current treatment recommendations.
Lithell et al. (2004) studied this question.
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