March 1, 2004DiabetesOpen Access

Electrically Stimulated Axon Reflexes Are Diminished in Diabetic Small Fiber Neuropathies

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Why the study?

Does intracutaneous electrical stimulation with laser Doppler imaging detect small fiber impairment in diabetic subjects?

Population

31 subjects: 12 diabetic subjects with small fiber neuropathies, 5 diabetic subjects without neuropathy, and…

Comparison

Intracutaneous electrical stimulation of… vs Healthy control subjects and diabetic subjects…

Design

Case-control

Authors

HKHeidrun H. KrämerJustus-Liebig-Universität Gießen MSMartin SchmelzUniversity of Mannheim FBFrank BirkleinJohannes Gutenberg University Mainz

Discussion

Member takes

Implication

Supports detection of small fiber impairment in diabetes via electrical flare testing; leaves open validation in prospective cohorts before clinical use.

Structured PICO

Does intracutaneous electrical stimulation with laser Doppler imaging detect small fiber impairment in diabetic subjects?

Population

31 subjects: 12 diabetic subjects with small fiber neuropathies (SFNs), 5 diabetic subjects without neuropathy (NO-Ns), and 14 healthy control subjects.

Intervention

Intracutaneous electrical stimulation of C-fibers with laser Doppler imaging (LDI) scanning

Comparator

Healthy control subjects and diabetic subjects without neuropathy

Outcome

Size and intensity of the flare on the dorsum of the foot and ventral thigh, and electrical thresholds for flare inductionsurrogate

Intracutaneous electrical stimulation with laser Doppler imaging is a sensitive tool to detect small fiber impairment in diabetic neuropathy.

Cite This Study

Krämer et al. (2004) studied this question.

synapsesocial.com/papers/6a8832ddb98a632b5e4fcf0a https://doi.org/10.2337/diabetes.53.3.769

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Implication

Supports detection of small fiber impairment in diabetes via electrical flare testing; leaves open validation in prospective cohorts before clinical use.