Zone electrophoresis in a sugar concentration gradient is an effective method for classifying and purifying enteroviruses based on their electrophoretic mobility.
Animal data on enterovirus mobility warrant lab validation only; leaves open human diagnostic or clinical translation.
Zone electrophoresis in a sugar concentration gradient is proposed as a complementary method for the biological classification of the enteroviruses. Under standardized experimental conditions it was found that the majority of the Coxsackie A viruses and the polioviruses have a common, low electrophoretic mobility. sackie A viruses and the polioviruses have a common, low electrophoretic mobility. The impression was gained that the ECHO viruses show the highest electrophoretic mobility, though in some cases there is overlapping with the Coxsackie Bs. The mobility of both of these groups is considerably higher than that of the other two. Zone electrophoresis appears to be an excellent method for the purification of the enteroviruses prior to the production of specific precipitating antibodies.
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Polson et al. (1962) studied this question.
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