Key result
In a healthy Turkish population, cardiac chamber sizes were significantly smaller in women compared to men, and left ventricular dimensions were generally larger than those reported in other populations.
Why the study?
Normal cardiac chamber reference values are primarily based on European or American cohorts, leaving differences across age, gender, and geographical regions in Turkish populations uncharacterized.
Cross-Sectional (n=1,154)
Yes
This study establishes the first normal echocardiographic reference values for a healthy Turkish population, highlighting age, gender, and regional differences.
Supports ethnicity-specific echocardiographic norms in Turkish adults; leaves open prospective validation before clinical adoption.
OBJECTIVE: Normal reference values for the cardiac chambers are widely based on cohorts from European or American populations. In this study, we aimed to obtain normal echocardiographic measurements of healthy Turkish volunteers to reveal the age, gender, and geographical region dependent differences between Turkish populations and other populations. METHODS: Among 31 collaborating institutions from all regions of Turkey, 1154 healthy volunteers were enrolled in this study. Predefined protocols were used for all participants during echocardiographic examination. Blood biochemical parameters were also obtained for all patients on admission. The American Society of Echocardiography and European Association of Cardiovascular Imaging recommendations were used to assess the echocardiographic cardiac chamber quantification. RESULTS: The study included 1154 volunteers (men: 609; women: 545), with a mean age of 33.5±11 years. Compared to men, women had a smaller body surface area, lower blood pressure and heart rate, lower hemoglobin, total cholesterol, lower low-density lipoprotein (LDL) levels, and higher high density lipoprotein (HDL) levels. Cardiac chambers were also smaller in women and their size varied with age. When we compared the regions in Turkey, the lowest values of left cardiac chamber indices were seen in the Marmara region and the highest values were observed in the Mediterranean region. Regarding the right cardiac indices, the Mediterranean region reported the lowest values, while the Black Sea region and the Eastern Anatolia region reported the highest values. CONCLUSION: This is the first study that evaluates the normal echocardiographic reference values for a healthy Turkish population. These results may provide important reference values that could be useful in routine clinical practice as well as in further clinical trials. (.
No takes yet. Share an insight, caveat, or question.
Özgen Şafak (2019) conducted a cross-sectional in Healthy volunteers (n=1,154). Echocardiographic evaluation was evaluated on Normal reference values for echocardiographic cardiac chamber quantification. In a healthy Turkish population, cardiac chamber sizes were significantly smaller in women compared to men, and left ventricular dimensions were generally larger than those reported in other populations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: