Acetaminophen, Isoniazid, and Hepatic Toxicity

Letters1 March 1991Acetaminophen, Isoniazid, and Hepatic ToxicityThomas S. Moulding, MD, Allen G. Redeker, MD, Gary C. Kanel, MDThomas S. Moulding, MDSearch for more papers by this author, Allen G. Redeker, MDSearch for more papers by this author, Gary C. Kanel, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-5-431_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Murphy and colleagues (1) recently reported a case of severe hepatotoxicity in a patient who had ingested both isoniazid and acetaminophen. We have noted the same association. In a recent study (2) of 20 isoniazid-associated deaths, we noted that one of the patients (case 5) had taken 8 acetaminophen tablets per day in the week before presenting with hepatitis. Another patient (case 14) may also have taken acetaminophen. The patient reported taking aspirin and some other over-the-counter medication for symptoms in the week or two before being admitted for jaundice. The physicians who elicited this history speculated,...References1. MurphySwartzWatkins RRP. Severe acetaminophen toxicity in a patient receiving isoniazid. Ann Intern Med. 1990;113:799-800. LinkGoogle Scholar2. MouldingRedekerKanel TAG. Twenty isoniazid-associated deaths in one state. Am Rev Resp Dis. 1989;140:700-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Thomas S. Moulding, MD; Allen G. Redeker, MD; Gary C. Kanel, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysisDrugs for TuberculosisIsoniazidDrugs for TuberculosisAcetaminophen HepatotoxicityHepatotoxicity of antibiotics and antifungalsChronic acetaminophen toxicity: a case report and review of the literatureOsteoarthritis IV: Clinical therapeutic trials and treatmentClinically Significant Interactions with Drugs Used in the Treatment of TuberculosisAcetaminophen Toxicity in ChildrenLesiones hepáticas por fármacosPopulation-based Incidence and Outcome of Acetaminophen Poisoning by Type of IngestionIsoniazid Drug and Food InteractionsIsoniazid Drug and Food InteractionsACETAMINOPHEN HEPATOTOXICITYDrug-induced hepatic injuryAnalgesic HepatopathyInfluence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid*Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cellsLiver injury during antituberculosis treatment: An 11-year studyHepatotoxicity Associated With Acetaminophen Usage in Patients Receiving Multiple Drug Therapy for TuberculosisAcute liver failureDrug-induced hepatotoxicityDrugs used in tuberculosis and leprosy 1 March 1991Volume 114, Issue 5Page: 431-431KeywordsAspirinHepatitis AIsoniazidToxicity ePublished: 1 December 2008 Issue Published: 1 March 1991 PDF downloadLoading ...