Why the study?
Does midodrine reduce symptom reporting and attenuate systolic blood pressure decreases after carotid sinus massage in older adults with vasodepressor carotid sinus syndrome?
Population
10 older adults with a history of unexplained syncope who displayed an asymptomatic decrease in systolic BP…
Comparison
Midodrine vs Placebo (placebo phase in a crossover design)
Design
RCT, randomized, crossover design, double-blind
Authors
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Supports midodrine for symptom control in vasodepressor CSS; extends pilot RCT evidence despite ambulatory BP rise.
Does midodrine reduce symptom reporting and attenuate systolic blood pressure decreases after carotid sinus massage in older adults with vasodepressor carotid sinus syndrome?
In a pilot study of older adults with vasodepressor carotid sinus syndrome, midodrine significantly reduced symptoms and attenuated systolic blood pressure drops after carotid sinus massage, though it increased 24-hour ambulatory blood pressure.
Moore et al. (2004) studied this question.
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