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May 1, 1994The Journal of Clinical Pharmacology

A Comparison of Postspace‐Flight Orthostatic Intolerance to Vasovagal Syncope and Autonomic Failure and the Potential Use of the Alpha Agonist Midodrine for These Conditions

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Why the study?

Does midodrine improve orthostatic intolerance in patients with post-space flight orthostatic hypotension, vasovagal syncope, or autonomic failure?

Population

Patients with post-space flight orthostatic hypotension, vasovagal syncope, or autonomic failure

Design

Review

Authors

SPStephen PiwinskiJJJoseph JankovicBaylor College of MedicineMMMary Ann McElligottMaryland University of Integrative Health

Discussion

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Implication

May support midodrine evaluation in vasovagal syncope; leaves open clinical utility pending prospective trials.

Structured PICO

Does midodrine improve orthostatic intolerance in patients with post-space flight orthostatic hypotension, vasovagal syncope, or autonomic failure?

P
Population
Patients with post-space flight orthostatic hypotension, vasovagal syncope, or autonomic failure
I
Intervention
Midodrine

Midodrine is proposed as a potential adjunctive treatment for post-space flight orthostatic hypotension and vasovagal syncope based on its mechanistic profile.

Cite This Study

Piwinski et al. (1994) studied this question.

synapsesocial.com/papers/6a883d5daaaef52b1e4df7f3https://doi.org/10.1002/j.1552-4604.1994.tb04988.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of orthostatic hypotension due to autonomic failure with a peripheral alpha‐adrenergic agonist (midodrine)1988 · 136 citations
  2. 2Human Autonomic Responses to Actual and Simulated Weightlessness1991 · 50 citations
  3. 3Role of the Capacitance and Resistance Vessels in Vasovagal Syncope1968 · 201 citations
  4. 4Vasodepressor Syncope1957 · 129 citations
  5. 5Provocation of Bradycardia and Hypotension by Isoproterenol and Upright Posture in Patients with Unexplained Syncope1989 · 657 citations